Yes, you can search for books by the 10 digit or 13 digit ISBN numbers. Just type the ISBN in the search window on the Basic Search page to perform the search. Do not include any dashes or spaces, just the numbers.
However, please be aware that searching by ISBN is not the best approach to searching for the books. This is because the same books may come with different ISBNs. If you fail to find a book by the ISBN, this does not necessarily mean the library does not have the book.